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DNA氧化损伤标志物8-羟基脱氧鸟苷及其检测 被引量：14

Detection of 8-hydroxy-2-deoryguanoslne,a marker for oxidative DNA damage
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摘要 活性氧基团引起的氧化损伤在许多慢性疾病中起着重要作用 ,8-羟基脱氧鸟苷 (8-hydroxy -2’ -deox yguanine ,8-OHdG)是DNA氧化损伤的修饰产物之一 ,可以通过高灵敏度 ,高选择性的检测手段来检测 ,目前已成为DNA氧化损伤中最常采用的生物标志物 (Biomarker)。本文主要介绍其来源。 Oxidative damage from reactive oxygen species including free radicals has been considered to play a vital role in many degenerative diseases. 8-hydroxy-2-deoryguanosine (8-OHdC) has been a biomarker for oxidative DNA damage. This paper introduces the source, detecting method and application of 8-OHdC.
作者 潘洪志 李蓉
机构地区 哈尔滨医科大学公共卫生学院
出处 《中国卫生检验杂志》 CAS 2003年第4期404-405,共2页 Chinese Journal of Health Laboratory Technology
基金 国家自然科学基金课题 (30 0 0 0 1 4 3)
关键词 DNA氧化损伤 8-羟基脱氧鸟苷 检测 生物标志物 衰老 自由基 气质联用分析法 8-hydroxy-2-deoryguanosine Detection
分类号 R339.38 [医药卫生—人体生理学]
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参考文献18

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二级参考文献4

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中国卫生检验杂志
2003年 第4期

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