甲亢伴粒细胞减低的放射性碘治疗

Radioactive iodine therapy on hyperthyroidism with granulocytopenia

目的 评估放射性碘治疗甲亢伴粒细胞减低的价值。方法 16例甲亢伴粒细胞减低患者 ,因服用抗甲状腺药物 (ATD)后出现粒细胞减低者 15例 ,发现甲亢时即伴有粒细胞减低者 1例。经内科升白治疗后 ,升白效果不明显或白细胞计数不稳定 ,仍无法使用ATD治疗 ,经采用13 1Ⅰ NaⅠ治疗 ,同时继续使用升白药物 ,而甲亢病情得以控制。结果 16例甲亢患者放射性13 1Ⅰ治疗前的白细胞水平为 ( 4 .1± 1.1)× 10 9/L ,13 1Ⅰ治疗后 2周为 ( 5 .1± 1.8)× 10 9/L ,13 1Ⅰ治疗后 1个月为 ( 5 .0± 1.8)× 10 9/L。比较13 1Ⅰ治疗前后白细胞水平 ,经t检验 ,P >0 .0 5 ,无明显差异。13 1Ⅰ治疗后 1个月 ,血清甲状腺激素明显下降 ,临床症状改善。

Objective To investigate the clinical valueof radioactive iodine therapy on hyperthyroidism with granulocytopenia.Methods This study consisted of 16 hyperthyroidism patients,15 cases complicated by antithyroid drug induced granulocytopenia.We prescribed 131 Ⅰ NaⅠ and granulocyte raised durgs for patients suffered from hyperthyroidism complicated with granulocytopenia.Results All patient's granulocyte number hadn't been decreased,however their clinical manifestations have been improving since 131 Ⅰ therapy.Conclusions Radioactive iodine therapy is optimum management for hyperthyroidism with granulocytopenia.