利培酮合并小剂量氯氮平治疗难治性精神分裂症疗效观察

The Study of the risperidone combining low dosage of clozapine treatment in the patients with resistant schizophrenics

目的 :探讨利培酮合并小剂量氯氮平治疗难治性精神分裂症疗效与安全性。方法 :采用门诊和住院病人开放式研究 ,对 34例符合CCMD - 2 -R精神分裂症诊断标准及难治性精神分裂症标准的患者采用利培酮 2～ 4毫克 /日合并氯氮平 5 0～ 15 0毫克 /日治疗。采用阳性与阴性症状量表 (PANSS)评定疗效 ,使用副反应量表(TESS)评价安全性。结果 :有 2 6例完成 6个月的疗程 ,占 76 4 % (2 6 / 34) ,总有效率为 6 5 3%。结论 :利培酮合并小剂量氯氮平治疗难治性精神分裂症有效 ,副反应小 ,安全性高 ,值得临床上选用。

Objective:To investigate the clinical efficacy and safety of the risperidone combining low dosage of clozapine treatment in the patients with resistant schizophrenics.Methods:34 patients were investigated in the 6 months open study,including the outpatients and inpatients.All the 34 patients were accord with the standard of schizophrenia in the CCMD-2-R and the standard of the resistant schizophrenics.All the patients in the study were treated with resperidone(2～4mg/d)combining low dosage of clozapine(50～150mg/d).The Positive And Negative Symptoms Scale(PANSS)and the Treatment Emergent Symptom Scale(TESS)were used to rate the clinical efficacy and the side effects of the patients.Results:26(26/34,76.4%)patients completed the study.The effective rate was 65.3%.Conclusions:The treatment of risperidone combining low dosage clozapine was effective for the resistant schizophrenics and the siad effects of the treatment were little.