利钾尿肽与心钠素摩尔比在心房纤颤时的作用

Role of kaliuretic peptide and molar ratio of kaliuretic peptide/ atrial natriuretic peptide in atrial fibrillation

目的 :探讨利钾尿肽 (KP)及 KP与心钠素 (ANP)摩尔比在心房纤颤 (房颤 )时的意义。方法 :用放射免疫 (放免 )分析法测定 2 3例阵发房颤患者和 2 4例持续房颤患者血浆中 KP与 ANP的水平 ,并以正常人作为对照。结果 :房颤患者血浆中 KP与 ANP的水平明显高于对照组 (P均 <0 .0 1) ,阵发房颤患者血浆中 KP/ ANP摩尔比显著低于正常对照组 (P<0 .0 1) ;持续房颤患者血浆中 KP/ ANP摩尔比与正常对照组相似 (P>0 .0 5 )。结论 :KP含量与

Objective: To investigate the role of kaliuretic peptide(KP) and molar ratio of KP/ atrial natriuretic peptide(ANP) in atrial fibrillation. Methods: The levels of plasma KP and ANP in 23 patients with paroxysmal atrial fibrillation (groupⅠ), 24 patients with persistent atrial fibrillation (>1 year, groupⅡ) and 20 healthy humans(groupⅢ) were determined with radioimmunoassay. Results: Compared with groupⅢ, the levels of plasma KP and ANP of the groupⅠ and groupⅡ were both higher (both P <0 01). Compared with groupⅢ, the level of KP/ANP of the groupⅠ was lower ( P <0 01), while that of groupⅡ was no substantial change ( P >0 05). Conclusion: The change of levels in ANP, KP and ANP/KP may play important role in atrial fibrillation.