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超速起搏预适应对缺血-再灌注心肌抗氧化酶活性的影响 被引量：2

Effects of overdriving pacing preconditioning on the activity of antioxidase in the coronary sinus during the ischem ia-reperfusion
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摘要 目的 :观察超速起搏预适应早期及延迟保护相对心肌缺血再灌注损害过程中血中一氧化氮 (NO)的影响。方法 :4 8只兔随机分为对照组 (C组 )、缺血再灌注组 (IR组 )、超速起搏预适应组 (PP组 )和延迟保护作用组 (DP组 )。观察超速起搏 (5 0 0 min1 )后缺血再灌注期冠状窦血一氧化氮 (NO)、超氧化物歧化酶 (SOD)、丙二醛 (MDA)的动态变化。结果 :PP组和 DP组较 IR组冠状窦血 NO含量在缺血再灌注期间明显增高 ,而SOD和 MDA含量明显减低。结论 :PP和 DP能减轻急性缺血再灌注期自由基对心肌的损害 ,NO参与了 PP与 DP的心肌保护作用 ,在 DP的发生中占重要位置。 Objective: To evaluate the effects of early and delayed overdriving pacing preconditioning on the concentration of nitric oxide(NO), superoxide dismutase(SOD) and malondialdehyde(MDA) in blood. Methods: Fortyeight rabbits were divided into control (C) group, ischemia reperfusion (IR) group, overdriving pacing preconditioning (PP) group and delayed protection (DP) group. The concentrations of NO, SOD, MDA in the coronary sinus were detected during the ischemiareperfusion. Results: The levels of NO in the coronary sinus of PP and DP group were higher than that of IR group, the levels of MDA of PP and DP group were lower than that of IR group. Conclusion: PP and DP could alleviate the injury by the oxygen free radicals during the myocardial ischemiareperfusion.
作者 林晓红 吴黎明
机构地区 福建医科大学附属协和医院急诊科
出处 《中国危重病急救医学》 CAS CSCD 2003年第8期482-484,共3页 Chinese Critical Care Medicine
基金 福建省科技基金资助项目 ( K2 0 0 5 9)
关键词 超速起搏 缺血预适应 再灌注损伤 一氧化氮 心肌缺血 pacing preconditioning ischemiareperfusion injury nitric oxide
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献12

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二级参考文献15

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共引文献12

同被引文献27

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二级引证文献18

中国危重病急救医学
2003年 第8期

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