摘要
作者应用细胞色素C还原法,研究了数种平喘药对经FMLP活化的人中性粒细胞(PMN_s)超氧阴离子释放过程的影响。结果显示:异丙肾上腺素、Colforsin和Azelastine对PMN_s释放O_2^-过程具有显著的抑制作用,双丁酰环腺苷酸仅具轻度抑制作用,而AM-682对此过程几无抑制作用。并对上述作用机理和临床意义作了讨论。
The effects ot an:ia.sthmatic drugs on respiration burst in activated human polymorphonuclear neutrophils (PMNs) with method of cytochrome C reduction were investigated. The results showed that isoprotereno], colforsin and azelastine indueed a dose-dependent inhibition of FMLP-caused superoxied production by human PMN_s. D butyryl cyclic AMP only had a mild inhibitory effect and AM-682 had no effect on human PMNs superoxide production. The mechanism of the effect and its significance in therapy of asthma are discussed.
关键词
平喘药
中性粒细胞
超氧阴离子
antiasthmatic drugs
PMN
superoxide
cAMP
asthma
