武汉地区汉族人群醛固酮合酶基因多态性与原发性高血压的关系

Association between aldosterone synthase gene polymorphism and primary hypertension in Chinese Han population

目的 :探讨武汉地区汉族人群醛固酮合酶 (CYP11B2 )基因 344C/T多态性频率分布特点及其与原发性高血压 (EH)的关系。方法 :以人群为基础进行EH病例 对照研究 ,应用PCR RELP技术对 2 11例武汉地区汉族人的CYP11B2基因 344C/T多态性进行分析。结果 :武汉地区汉族人群CYP11B2基因 344C/T多态性以TT和CT为主要基因型 ,C等位基因较少见 ,其频率为 2 4 % ,明显低于文献报道的欧洲白种人 (P <0 .0 1) ,亦低于日本人 (P <0 .0 5 )。CYP11B2基因 344C/T多态性与EH无明显相关性 (P >0 .0 5 )。结论 :武汉地区汉族人群CYP11B2基因 344C/T多态性频率分布有着与欧洲白种人以及日本人不同的特点 。

Objective:To investigate the frequency of variant aldosterone synthase (CYP11B2) gene and its relation to primary hypertension in Chinese population.Methods:Population based case control study was conducted using PCR RELP techniques to explore the relation between aldosterone synthase gene polymorphism and primary hypertension in 211 subjects from Chinese Han nationality.Results:Both TT and CT were major frequent genotypes. The frequency of allele C was 0.24 and it was significantly lower in Chinese compared with those reported in Caucations (P< 0.01 ) and in Japanese (P< 0.05 ). There was no significan association between aldosterone synthase gene polymorphism and primary hypertension in the group of 211 Chinese individuals.Conclusion:There is apparent difference in the distribution of C allele frequency of CYP11B2 gene between Chinese Han nationality and other ethnic populations. No significant association is observed for aldosterone synthase allele status and primary hypertension in Chinese Han population.