摘要
本次试验研究表明:实验大白鼠吸入EHFV气溶胶后第5天部份实验鼠血中即可检测到EHFV抗原,14天后EHF抗原全部消失,病毒血症可持续7天左右;第7天肺组织中可检测到EHF抗原其IF强度和病毒感染滴度亦随感染时间而增高。EHF抗原阳性的肺组织中IgA水平显著高于EHF抗原阴性的肺。肺组织中IgA的增高可能有促进EHFV的感染,这对研究EHFV气溶胶感染提供了一定的科学依据。
The results of this experiment indicate that EHFV antigen appeared in blood of some rats on the 5th day after inhalation of EHFV aerosol, and disappear on the 14th day. Virernia might exist for about 7 days. The 7th day EHFV antigen became positive in the lungs, and both its titre and virus titre increased in parallel as the time went on. The amount of IgA in EHFV antigen positive lungs was significantly more than that of IgA in EHFV antigen negative. An elevation of lung IgA may enhance infection of rats with EHFV. This fact lays the scientific foundation for the study of EHFV infection by aerosol.
