脑舒宁对小鼠实验性急性脑缺血的保护作用

Protective effect of Naoshuning(NSN)on the experimental acute cerebral ischemia in mice

目的 观察脑舒宁对小鼠急性脑缺血损伤的保护作用。方法 采用小鼠双侧颈总动脉和迷走神经结扎法制作脑缺血模型并观察脑舒宁对其的影响。结果 急性脑缺血时脑内丙二醛 (MDA)、一氧化氮 (NO)明显增加 (P <0 .0 5 ) ,超氧化物歧化酶 (SOD)明显减少 ,而脑舒宁可明显增加SOD ,降低MDA、NO(P <0 .0 5 )。

OBJECTIVE To observe the protective effects of NSN on cerebral ischemia reperfusion injury. METHOD The method of ligating both common carotids and vagus was used to make acute cerebral ischemia reperfusion injury in mice.RESULTS NSN increased notably brain SOD content, as well as decreased brain MDA and NO content on the cerebral ischemia( P <0.05). CONCLUSION NSN may have protective effect on the cerebral ischemia injury in mice.