奥美拉唑治疗急性重型颅脑损伤并发应激性溃疡及胃酸变化

Effect of Losec on stress ulcer followed acute severe craniocerebral injury and gastric acid change

目的 探讨奥美拉唑 (洛赛克 )和雷尼替丁对重型颅脑损伤并发上消化道出血患者胃酸分泌的影响。方法 78例患者随机分组 :洛赛克组、雷尼替丁组 ;所有病例均于应用抑酸药前、用药后 3,12 ,2 4 ,72h监测胃液 pH及消化道出血情况。 结果 重型颅脑损伤并发上消化道出血时胃液 pH值低 ,洛赛克组较雷尼替丁组能显著升高胃内 pH(P <0 .0 5 )。 结论 重型颅脑损伤并发上消化道出血胃酸呈高分泌状态。洛赛克对应激性溃疡的胃酸抑制和止血效果均优于雷尼替丁。

OBJECTIVE To evaluate the efficacy of Losec and Ranitidine on gastric acid secretion on stress ulcer followed acute severe craniocerebral injury. METHOD Seventy eight patients were divided randomly into two groups: Losec group and Ranitidine group. Gastric pH monitoring were conducted before antiacid and 3 hours、12 hours、24 hours、72 hours after antiacid and define homeostatic time.RESULTS In stress ulcer followed acute severe craniocerebral injury patients the intragastric pH was significantly decreased. Losec could block the decrease of the intragastric pH comparing with Ranitidine group ( P <0.05). CONCLUSION These was hypersecretion of the gastricacid in stress ulcer followed acute severe craniocerebral injury patients. Losec Could better block the decrease of the intragastric pH and homeostasis than that Ranitidine.