牙周炎患者龈沟液β_2-微球蛋白的研究

Study of β_2-Microglobulin in Gingival Crevicular Fluid in Periodontitis Patients

以 RIA 检测了成人牙周炎(AP)10人20个牙治疗前后和牙周健埭者(H)10人21个牙龈沟液(GCF)中β_2-微球蛋白(β_-MG)的含量并记录临床指数 PLI、GI、PD、AL。结果显示:AP 组 GCF 中β_2-MG 的含量显著小于 H 组(P<0.01);在 H 组、AP 组混合情况下和 AP 组内,β_2-MG 含量只与 PD、AL 呈显著负相关(P<0.05);牙周治疗后,随着牙周破坏程度的减轻(P<0.01),β_2-MG 的含量相应升高(P<0.05),说明 GCF 中β_2-MG 与牙周破坏程度有关,并可能参与了 AP 的局部免疫反应。

This article examined the β_2-microglobulin content in gingival crevicular fluid(GCF)from 20 teeth in treatment of 10 patients with adult periodontitis(AP)and 21 teeth of 10 normal controls(H)and recorded the clinical indices of PLI,GI,PD,AL by radio immune assay(RIA). The result showed that the β_2-microglobulin in GCF in the adult periondontitis was found to be significantly reduced compared with the normal controls'(P<0.01)and that β_2-microglobulin in GCF was negatively correlated to PD and AL in the AP group and in the mixture of H group and AP group.After periodnotal treatment,the β_2-microglobulin content was increased(P<0.01)when the degree of periodontoclaisa was reduced (P<0.05).The above indicates that there is some relationship between the degree of periondontoclasia and the β_2-microglobulin in GCF which may have a hand in partial immune response of the adult periodontitis.