超短波辅助治疗慢性阻塞性肺疾病患者气道炎症的临床研究

Clinical study of ultrashortwave therapy on airway inflammation in patients with chronic obstructive pulmonary disease

目的 研究超短波对慢性阻塞性肺疾病(COPD)患者气道炎症及肺通气功能的影响并探讨其作用机理。方法 将74例急性发作期COPD患者分为超短波治疗组42例和对照组32例。超短波治疗组在常规治疗的基础上给予超短波治疗,对照组行常规治疗。两组患者均在治疗前、后分别记录其临床症状及体征,并检测血中白介素8(IL-8)、肿瘤坏死因子α(TNF-α)、粒细胞集落刺激因子(G-CSF)以及肺通气功能指标中用力肺活量(FVC)和第1秒用力呼气量(FEV_(1.0))。结果 与对照组比较,超短波治疗组治疗后其咳嗽、痰液性状、痰量及干啰音等临床症状与体征的显效好转率显著提高(P<0.05),血清IL-8、TNF-α、G-CSF均显著降低(P<0.05),FVC％pred、FEV_(1.0)％pred明显升高(P<0.05)。IL-8含量与 FEV_(1.0)呈负相关(r=-0.87,P<0.05),TNF-α含量与FEV_(1.0)呈负相关(r=-0.72,P<0.05)。结论 超短波辅助治疗COPD具有减轻气道炎症、提高肺通气功能的作用。

Objective To investigate the effect of ultrashortwave therapy on chronic obstructive pulmonary disease(COPD),and to explore the mechanism of ultrashortwave on COPD. Methods Seventy-four patients were divided into 2 groups: a treatment group, in which 42 patients were treated with both ultrashortwave and regular treat- ment; a control group, in which 32 patients were treated with only regular treatment. Clinical symptoms and signs were recorded,the serum samples were obtained and pulmonary function indices such as FVC and FEV_(1.0) were tested before and after the treatment, respectively. The interleukin-8 (IL-8 ), tumor necrosis factor-alpha (TNF-α) and granulocyte colony-stimulating factor(G-CSF) in serum were determined by immunoassay technique. The relationship between IL-8, TNF-α, G-CSF and FVC, FEV_(1.0) were analysed. Results Compared with that of control group, the clinical manifestations were improved and the IL-8,TNF-α, G-CSF were decreased more significantly after the treat- ment with ultrashortwave(P < 0. 05 ). FVC, FEV_(1.0) increased more significantly in the treatment group than in control group(P < 0. 05 ). FVC and FEV_(1.0) is negatively relative to IL-8 (r=-0. 87,P < 0. 05 ) and TNF-α(r = -0. 72,P < 0. 05). Conclusion Ultrashortwave therapy is effective for improving the ventilation by antiinflammation in airway in COPD patients.