民航飞行人员的血清过氧化脂质水平

The serum lipid peroxide level of civil aircrew members

目的 观察职业性受高空宇宙射线照射的民航飞行人员血清过氧化脂质水平及抗氧化能力。方法 以化学比色法测定血清过氧化脂质、超氧化物歧化酶及总抗氧化活性 ;以宇宙辐射航线有效剂量计算软件CARI 6估算有效剂量。结果 飞行人员血清过氧化脂质、超氧化物歧化酶、总抗氧化活性均显著高于地面人员 (P <0 0 5 )。随着年均飞行小时、年均有效剂量的增加血清过氧化脂质水平有增加的趋势 ,但和累积飞行小时累积有效剂量及飞行人员的年龄没有平行关系。近期内飞行连续性变化 ,过氧化脂质水平也呈现相应的动态变化。结论 飞行人员体内脂质受到宇宙射线的氧化损伤 ,同时机体的抗氧化能力代偿性增强 ;近期飞行负荷、受照射频率明显影响血清过氧化脂质水平 ;过氧化脂质或可作为飞行人员辐射防护的监测指标。

Objective To observe serum lipid peroxide level and antioxidant capacity in civil aircrew members who occupationally exposed to cosmic radiation at high altitude. Methods Serum lipid peroxides (MDA),superoxide dismutase (SOD) and total antioxidant acitivity (TAO) were all determined by chemical colo-rimetry.The effective doses were estimated in accordance with CARI-6. Results The three indicators in the aircrew members were all significantly higher than those of ground personnel ( P <0.05):their MDA,SOD,TAO levels were (4.09±1.1)nmol/ml,(126.0±17.1)U/ml,(22.01±4.6)U/ml,while those in the ground personnel were (3.79±0.7)nmol/ml,(119.5±10.5)U/ml,(20.02±3.9)U/ml,respectively.The serum MDA levels exhibited a trend of increase with average annual flight hours and average annual effective doses,but were not parallel with total hours service in flying and accumulative effective doses and ages.The MDA showed corresponding dynamic changes with the changes in the flight continuity over a recent period of time. Conclusions The lipids in the body of aircrew members suffer oxidation damage from cosmic radiation and the antioxidant capacity of the body shows a compensatory increase.The serum lipid peroxide levels are affected obviously by flight burdens and the frequency exposed to cosmic radiation recently.The serum lipid peroxides might be used as a monitoring indicator in cosmic radiation protection for aircrew members.