健脾降逆消痞方治疗肝动脉栓塞化疗术后消化道毒副反应32例疗效观察

Jianpi Jiangni Xiaopi Tang for Toxic and Side Effects of Digestive Tract After Chemotherapy by Hepatic Artery Embolism: A Clinical Observation of 32 Cases

目的:观察健脾降逆消痞方对肝动脉栓塞化疗术后消化道毒副反应的治疗效果。方法:将62例经皮股动脉穿刺肝动脉灌注化疗栓塞治疗术(TACE)后有明显消化道毒副反应的患者随机分为2组,治疗组32例以健脾降逆消痞方(由赭石、党参、白术、茯苓、旋覆花、法半夏、厚朴、炒麦芽、干姜、黄连、枳实、甘草组成)治疗;对照组30例静滴胃复安、口服吗丁啉治疗。结果:健脾降逆消痞方能明显减轻消化道毒副反应症状,与对照组比较,差异有非常显著性意义(P<0.01)。结论:健脾降逆消痞方治疗肝动脉栓塞化疗术后消化道毒副反应安全有效,未发现不良反应。

Objective: To observe the curative effect of Jianpi Jiangni Xiaopi Tang (JJXF) for toxic and side effects of digestive tract after chemotherapy by hepatic artery embolism. Methods: 62 cases with marked toxic and side effects after transdermal femoral artery - hepatic artery chemotherapy embolism were allocated to 2 groups randomly. The treatment group (32 cases) treated by JJXF (composed of Haematitum, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria, Flos Inulae, Rhizoma Pinelliae Preparata, Cortex Magnoliae Of-ficinalis, Fructus Hordei Germinatus, Rhizoma Zingiberis, Rhizoma Coptidis, Fructus Aurantii Immaturus and Radix Glycyrrhizae), and the control group (30 cases) by Metoclopra - mide and domperi-doni. Results: JJXF can markedly relieve the toxic and side effects of digestive tract , showing very significant difference in comparison with control group ( P< 0. 01). Conclusion: JJXF is effective for toxic and side effects on digestive tract after chemotherapy by hepatic artery embolism, and is safe without adverse effect.