高血压患者心肌耗氧量与左心室肥厚的关系

Relation between the myocardium oxygen consumption and left ventricular hypertrophy

目的 研究高血压患者心肌耗氧量与左室肥厚的关系。方法 对 75例高血压患者动态监测 2 4小时血压并自动计算心率血压乘积 ,超声心动图测定室间隔、左室后壁厚度及左室舒张末内径 ,并按Devereux校正公式计算左室质量、左室质量指数 (LVMI) ,分析各参数间的关系。结果 昼夜节律消失者夜间的心率血压乘积、左室质量指数分别为 (95 86± 2 0 38)mmHg·次·min-1、(15 5± 2 7) g/m2 ,与昼夜节律存在者 (794 1± 14 6 )mmHg·次·min-1、(136± 2 2 )g/m2 相比均增高 ,其差异有统计学意义 (P <0 .0 1)。夜间的心率血压乘积和LVMI中度相关 (r =0 .5 3,P <0 .0 1)。结论 夜间心率血压乘积的增加可导致左室肥厚。

Objective To evaluate the relation between the myocardium oxygen consumption and left ventricular hypertrophy in the hypertensive patients.Methods 75 essential hypertensive patients were selected.The blood pressures were measured with ambulatory blood pressure monitoring and the left ventricular mass index(LVMI) was measured with echocardiography according to Devereux correction formula.Results The night double(rate pressure) product (nDP) and LVMI of the patients whose blood pressure day night rhythms are absent[( 9586 ± 2038 ) mm Hg·beat·min -1 ,(155±27) g/m 2]are higher than those of the patients whose are present[( 7941 ± 146 )mm Hg·beat·min -1 ,(136±22) g/m 2], P < 0.01 .The relation between the nDP and LVMI is medium in linear regression ( r = 0.53 , P < 0.01 ).Conclusion The increase of night double product can cause left ventricular hypertrophy in the hypertensive patients.