病毒性脑炎患者血清中神经元特异性烯醇化酶含量的检测分析

Detection of of Serum Neuron-specific Enolase Activity in Patients with Acute Viral Encephalitis

目的探讨病毒性脑炎患者血清中神经元特异性烯醇化酶 (NSE)含量与脑炎的关系。方法采用酶联免疫吸附法分别测定了 32例病毒性脑炎患者血清中的NSE ,并与 2 0例非病毒性脑炎患者作对比。结果病毒性脑炎组患者血清中NSE高于对照组 (P <0 .0 5 ) ,病毒性脑炎伴神经功能重度障碍组NSE浓度显著高于神经功能轻中度障碍组和对照组 ;神经功能轻中度障碍组NSE浓度显著高于对照组 (P <0 .0 5 )。结论病毒性脑炎患者血清NSE含量增高 ,其升高程度与神经功能障碍程度有关。检测其在血清中的含量对脑炎患者的脑损伤程度和预后判断具有临床实用价值。

ObjectivesTo explore the interrelation between the activity of serum neuron specific enolase (NSE) in patients with acute viral encephalitis(AVE). and severity of the disease.MethodsSerum NSE activities in 32 patients with AVE and 20 non viral encephalitis patients served as controls were estimated by radioimmunoassay (RIA).Their blood samples were obtained within 72 hours after the onset of encephalitis.ResultsSerum NSE activities in patients with AVE were significantly higher than those in control group (P<0.05). Serum NSE activities in AVE patients accompanying with severe disorders of neurological function (such as coma) were significantly higher than those in AVE patients with mild /moderate grade of disorders and control group; whereas those in AVE patients with mild/moderate disorders were obviously higher than in the controls (P<0.05).ConclusionThe elevated degree of serum NSE activity in AVE patients is closely related with the severity of their neurofunctional disorders. Detection of serum NSE activity possesses clinical significance for judgment of cerebral damage extent and prognosis in these patients.