α_1受体阻滞剂联合抗生素治疗慢性前列腺炎的疗效观察

Clinical assessment of treatment of chronic prostatitis with α_1 adrenoceptor blocker and antibiotic

目的 观察α1肾上腺素能受体阻滞剂合用抗生素治疗慢性前列腺炎的疗效。探讨α1受体阻滞剂在治疗慢性前列腺炎中的作用机制。方法 将 74例慢性前列腺炎患者随机分为两组 ,实验组 38例口服α1受体阻滞剂 (可派 )和左旋氧氟沙星 ,对照组 36例仅口服左旋氧氟沙星 ,均治疗 6周 ,观察治疗前后尿动力学指标 ,前列腺液常规及前列腺炎症状评分的变化。结果 实验组总有效率 81 5 % ,对照组为36 7% ,合用α1受体阻滞剂治疗慢性前列腺炎较单用抗生素治疗更为有效 (P <0 0 5 )。结论 α1受体阻滞剂可降低尿道压力 ,减轻前列腺内尿道返流 。

Objective To investigate the efficiency of α 1 adrenoceptor blocker in treatment of chronic prostatitis. Methods 74 patients with chronic prostatitis received either α 1 adrenoceptor blocker ( terazosin) combined with levofloxacin or the latter alone for 6 weeks. Urodynamic indexes, symptoms scores and prostatic secretion examination were recorded before and after therapy. Results Terazosin combined with levofloxacin was significantly more effective than that of levofloxacin alone in the treatment of chronic prostatitis. Conclusion α 1 adrenoceptor blocker can reduce the intraurethral pressure, prevent urethroprostatic reflux, improve urinary symptoms of chronic prostatitis.