乳腺癌淋巴结转移与癌组织中白细胞介素-6及受体的关系

Relationship between the expression of interleukin-6,interleukin-6 receptor and lymph node metastasis in breast carcinoma

目的 研究乳腺癌淋巴结转移与活体癌组织中白细胞介素 6(IL 6)及白细胞介素 6受体 (IL 6R)表达的关系。方法 应用病理学诊断方法检查腋淋巴结有无癌细胞转移 ,采用逆转录 聚合酶链反应 (RT PCR)的方法检测乳腺癌组织IL 6、IL 6R的mRNA表达。结果 IL 6组中 ,有腋淋巴结转移的癌组织中IL 6表达率为 47.619% (10 /2 1) ,无转移的为 82 .979% (3 9/4 7) ,差异有非常显著性 (χ2 =9.0 13 ,P <0 .0 1) ;IL 6R组中 ,有淋巴结转移的IL 6R表达率为 3 8.0 95 % (8/2 1) ,无转移的为 89.3 62 % (4 2 /4 7) ,差异有非常显著性 (χ2 =19.60 ,P <0 .0 0 1)。结论 乳腺癌组织中的IL 6及IL

Objective To study the relationship between lymph node metastasis and the expression of interleukin-6 (IL-6),interleukin-6 receptor (IL-6R) in breast cancerous tissues.Methods The axillary lymph nodes were examined by pathological method to determine whether metastasis occurred.Reverse transcription-PCR was used to detect the expression of IL-6 and IL-6R mRNA in breast cancerous tissues.Results In the IL-6 group,the rate of IL-6 positive expression with or without axillary lymph node metastasis was 47.619 % (10/21) and 82.979 % (39/47) respectively with the difference being very significant (χ 2=9.013,P<0.01).In the IL-6R group,the rate of IL-6R positive expression with or without axillary lymph node metastasis was 38.095 % (8/21) and 89.362 % (42/47) with the difference being very significant (χ 2=19.60,P<0.001).Conclusion The expression of IL-6 and IL-6R is significantly correlated with lymph node metastasis and prognosis of breast carcinoma.