C型利钠肽在慢性肺心病中的变化及临床意义

Changes of plasam a c-type natriuretic peptide levels and clinical significance in patients with chronic pulmonary heart disease

目的探讨C型利钠肽 (CNP)在慢性肺心病中的作用和临床意义。方法选择慢性肺源性心脏病 30例 ,分急性期和缓解期 (分别为B1和B2组 ) ,30例健康人为对照组 (A组 )。各组均采用放免法测定血浆CNP、肾上腺髓质素 (ADM )。结果临床实验组血浆CNP和ADM水平均高于正常对照组 (P <0 .0 1) ;血浆CNP水平B1高于B2 (P <0 .0 5 ) ;血浆ADM水平B1高于B2 (P <0 .0 1)。血浆CNP与血浆ADM水平呈正相关 (r=0 2 83,P <0 .0 5 )。结论CNP参与了慢性肺心病的病理生理过程 ;并且通过观察血浆CNP水平变化 ,可以反映肺心病的病情。

Objective To explore the role and clinical significance of plasam c -type natriuretic peptide(CNP) levels in patients with chronic pulmonary heart disease(PHD).Methods Plasam a CNP and adrenomedullin(ADM) were measured by radioimmoassay in 30 cases of PHD at different stages(group Bland B2) and in 30 cases normal subjects (group A). Results Levels of plasam a CNP and ADM in group B and group A were significally elevated than that of control group(P<0.01).CNP at acute exacerbation stage in group B(B1) was higer than that at stable stage in group B(P<0.05).Plasam ADM in group B1was significally higer than that in group B2,Meanwhile,there was also correlation between CNP and ADM(r=0.283,P<0.05).Conclusion The CNP participated in the pathophsiology changes in PHD.Levels of plasam a CNP can reflect the severity of the above series of diseases,presumably CNP may prevent the deterioration of pulmonmary hypertension.