4-羟基-3-羧基苯甲醛水杨酰腙及其配合物抑菌活性初步研究

Studies on bacteriostasis activities of 3-carboxyl-4-hydroxybenzaldehyde salcyloyl hydrazone and their complexes

目的 研究配体 4-羟基 - 3 -羧基苯甲醛水杨酰腙 (H2 L)及其配合物的抑菌活性。方法 合成配体 4-羟基 - 3 -羧基苯甲醛水杨酰腙及其配合物 ,采用K -B法检测其对金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长抑制作用。结果 配体H2 L及其金属配合物能抑制金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长 ,形成抑菌环 ,尤其配体H2 L形成抑菌环直径最大。结论 配体H2 L及其金属配合物均有一定的抑菌作用 ,配体H2 L的抑菌作用最强。

Objective To study bacteriostasis activities of 3-carboxyl-4-hydroxybenzaldehyde salcyloyl hydrazone(H 2L 4) and their complexes.Methods Ligand H 2L and their complexes were synthesized. The bacteriostasis activities of H 2L and their complexes in vitro were tested with K-B method. Results It is a dramatic bacteriostasis activity on Staphyloccus aureus, Escherichia coli, Bacillus subtilis. Ligand H 2L Bacteriostasis ring diameter is largest especially. Conclusions: Ligand H 2L and their complexes have bacteriostasis activity in vitro. Bacteriostasis activities of ligand H 2L are strong est .