摘要
实验分两组,通过喂饲致石饲料造成地鼠胆石症模型,一组不予治疗,另一组在造模同时用茵陈蒿汤加味灌胃。30天后,治疗组和模型组地鼠胆囊结石成石率分别为71.4％和100％(P<0.05);巨大结石比例为9.58％和15.28％(P<0.05)。治疗组成石指数小于1;模型组大于1。模型组88％的地鼠胃窦粘膜有明显炎性改变;治疗组仅17％,其余基本正常(P<0.01)。
We made the animal model of cholelithiasis by using a special diet rich in refined carbohydrates, animal fats and choleterols in hamsters. These hamsters were divided into two groups, the model group, which was only fed with special foods, and the drug group, which was given MHX by p.o. as well。After 30 days, the rates of gallstons formation in the model and drug sroups were 100％ and 71.4％ respectively (P<0.05). The percentages of huge stons (diameter≥0.05mm)were 15.28％ and 9.58％(P<0.05)。The LI of gallbite in the drug group was less than I hut it was higher than 1 in the model. There was marked inflammation of gastric antrum mucosa in moled group. The mobidity rate was 80％ in model and was only 17％ in drug group(P<0.01).
