CGC-MS联用对中毒患者毒物快速分析的研究

Stady on Fast Analysis of the Poisons in Clinical Intoxicated Patients by Capillary Gas Chromatography-mass Spectrometry

目的 应用毛细管气相色谱 -质谱 (CGC -MS)联用技术 ,对服用毒物自杀中毒患者尿、胃内容物等样品进行分析鉴定研究。方法 样品经酸化和碱化、乙醚提取 ,油状物样品用甲醇溶解稀释 ,然后进行CGC -MS分析。结果 检出和确证了患者服用的毒物分别为敌敌畏、司可巴比妥加苯巴比妥和苯巴比妥加地西泮。结论 本法简便、快速、准确 ,为医院临床抢救提供了可靠的依据。

Aim To report a new method for detection of unknown poisons in clinical intoxicate patients by CGC-MS.Methods The urine and gastric content samples were extracted with ethyl ether after acidfication and alkalification.The extracts was dried out under air stream and residue was dissolved in chloroform for CGC-MS analysis.It could be searched from the Data file of computer in MS.Results We have been detected and identified several samples from three intoxicate patients.We have been detected and identified several samples from three intoxicate patients.It was DDVP,Sucbabituricl,Benbabituricl and Diazepam.Conclusion This method is rapid,simple and sensitive.These results provided a scientific data for the rescre of intoxicate patients.