肺结核患者抗结核期间的肝代谢功能研究

Study on the Liver Metabolism Function in Antituberculosis Period of Pulmonary Tuberculosis Patient

目的 了解抗结核药物引起肺结核患者的肝损害。方法 用RP -HPLC检测 6 8例正常人 ,6例尚未使用、5 2例已使用抗结核药物肺结核患者的唾液咖啡因清除率 (SCL)。结果 6 8例正常人和 6例未用抗结核药物肺结核患者的SCL在正常值范围 ,5 2例已使用抗结核药物肺结核患者的SCL在异常范围。结论 用药时间延长 ,肝代谢功能越低 ,肝损害越明显。

Aim To investigate the liver damages caused by antituberculosis drugs.Method The saliva caffeine clearance (SCL) was determined by RP-HPLC method in 68 healthy adults,6 tuberculosis patients without using antituberculosis drugs and 52 tuberculosis patients used antituberculosis drugs.Result The SCL of 68 healthy adults and 6 tuberculosis patients without using antituberculosis drugs was normal.The SCL of 52 tuberculosis patients used antituberculosis drugs was abnormal.Conclusion As time of treatment elongation,the liver metabolism function become lower.So antituberculosis drugs can damage liver function.