45例不稳定心绞痛患者心肌酶的测定与冠状动脉造影的分析

An observation on the interrelation between the levels of cardiac troponin Ⅰ and creatine Kinase-MB and the degree of pathologic change of coronary artery in 45 patients with unstable angina pectoris

目的 探讨肌钙蛋白Ⅰ (cTnⅠ )及肌酸激酶同工酶 (CK MB)阳性的不稳定心绞痛患者 ,与其冠状动脉病变的关系 ,从而判断病人的预后。 方法 在心绞痛发作后的 4、8、12、16小时采血 ,测定 4 5例不稳定心绞痛患者的cTnⅠ及CK MB ,1周内行冠状动脉造影检查。 结果 1 cTnⅠ阳性的不稳定心绞痛患者较cTnⅠ阴性的不稳定心绞痛患者 ,其临床症状重 ,冠状动脉病变严重 ,复杂并有显著差异 (P <0 0 1) ,2 CK MB阳性的不稳定心绞痛患者 ,较CK MB阴性的不稳定心绞痛患者其临床症状重 ,冠状动脉病变严重、复杂 ,亦有显著差异 ( P <0 0 1) ,3 cTnⅠ阳性的不稳定心绞痛患者与CK MB阳性的不稳定心绞痛患者比较则无显著差异 (P >0 0 5 )。 结论 cTnⅠ与CK MB阳性者有对不稳定心绞痛患者的冠状动脉病变具有预测性。

Objective To observe the interrelation between the levels of cardiac troponin Ⅰ(cTnⅠ) and creatine Kinase-MB(CK-MB) and the degree of pathologic change of patients with coronary artery unstable angina pectoris Methods The cTnⅠ and CK-MB were examined after the patients were attacked by unstable angina pectoris 4、8、12、16 hours and the coronary arteriography was examined after a week The levels of cTnⅠ and CK-MB were compared with the clinical symptoms and the de- gree of the pathologic change of coronary artery Results The serious degree of the clinical symptoms was not only related to the degree of the pathologic change of coronary artery,but also to the levels of cTnⅠ and CK-MB Conclusion The levels of cTnⅠ and CK-MB could help to prognose the degree of the pathologic change for the patients with unstable angina pectoris