糖尿病视网膜病变患者血浆D-二聚体、P-选择素变化的分析

Study on the Variation of Plasma D-Dimer and P-selectin in Diabetic Retinopathy

目的 探讨糖尿病视网膜病变(DR)与D-二聚体、P-选择素的关系。方法 用Sysmex1500全自动血凝仪及BIO-TEK酶标仪对31例正常对照组,21例单纯糖尿病组(DM),及17例DR组的D-二聚体、P-选择素进行检测并分组比较。结果 DM及DR二组血浆P-选择素指标均显著高于正常对照组(P<0.05,0.01);DR组P-选择素高于DM组(P<0.05); DM组D-二聚体与正常对照组无显著性差异,而DR组D-二聚体显著高于DM组及正常对照组(P<0.05)。结论 DR患者存在不同程度继发纤溶亢进及血小板活化征象。

Objective To explore the D-dimer and P-selectin of diabetic retinopathy. Methods Detect the D-dimer and P-selectin in 31 cases normal person, 21 cases diabetes mellitus (DM) and 17 cases diabetic retinopathy (DR) patients with Sysmex CA-1500 automated blood coagulation analyzer and BIO-TEK EOSA Reader, data grouping and treatment with analysis of variance.Results Comparison between control group and DM、DR group, the P-selectin in DM and DR group is increases markedly(P <0.05 and P < 0.01,respectively) ; DR's P-selectin is higher than DM's(P <0.05).No statistical difference in D-dimer between DM's and control group's. But DR's D-dimer is higher than DM' s and control group' s( P < 0.05). Conclusion DR patients have easily fibrinolytic activities and blood platelet activation sign.