口腔黏膜下纤维性变S100蛋白表达

Expression of S100 in oral submucose fibrosis

目的 :研究口腔黏膜下纤维性变中S10 0蛋白的表达水平及其与正常口腔黏膜上皮、异常增生上皮的比较。方法 :应用免疫组织化学 (SP)法 ,检测 10例口腔黏膜下纤维性变、10例上皮异常增生、8例正常口腔黏膜上皮S10 0蛋白表达水平 ,并作对比研究。结果 :S10 0蛋白在正常口腔黏膜上皮中无表达 ,口腔黏膜下纤维性变上皮中和异常增生上皮中S10 0的阳性表达率为 5 0 %,后两者的阳性表达率明显高于正常黏膜组上皮 (P <0 .0 5 ) ;口腔黏膜下纤维性变组与异常增生上皮组比较 ,差异无显著性 (P >0 .0 5 )。结论 :口腔黏膜下纤维性变发生发展与S10 0蛋白过表达密切相关 ,S10 0蛋白表达强度与异常增生上皮表达强度一致。

Objective To study the expression of S100 in oral submucose fibrosis(OSF).Methods Immunohistochemistry assay was performed on 10 cases of OSF,10 cases of oral epithelial dysplasia(OED) and 8 cases of normal oral epithelium using monoclonal antibody against S100 protein.Results S100 did not express in the normal oral muscosal epithelium.The S100 positive nuclear staining was found in 50% of the OSF and OED cases,which was significantly higher than that in the normal oral epithelium (P<0.05). But the positive staining in the OSF and OED cases had no difference (P> 0.05).Conclusion S100 expression is closely related to the development of OSF and OED.The positive staining expression in the OSF and OED cases is the same.