低精蛋白胰岛素联合二甲双胍治疗2型糖尿病的临床观察
摘要
我们观察了2001年6月～2002年6月应用低精蛋白胰岛素(诺和灵30R)(丹麦诺和诺德公司生产)治疗的2型糖尿病(DM)66例,有严重感染和肝肾功能不全的病人不列入观察范围.66例2型DM病人均因口服磺脲类药物失效,或并发血管神经病变,或血糖控制不理想均需胰岛素治疗.66例病人均符合1998年WHO规定的2型DM的诊断标准,其并发症均经肌电图、检眼镜(眼底镜)、24小时尿蛋白定量确诊.现就观察结果报告如下.
参考文献5
-
1Reaven GM. Role of insulin resistance in human disease.Diabetes, 1998,37:1595～1607
-
2Haffner SM,Miettinen H. Insulin resistance implications for type Ⅱ diabetes mellitus and coronary heart disease. Am J Med,1997,103:152～162
-
3Cusi K, Consoli A, Fronzo RA. Metabolic effects of metformin in non - insulin dependent diabetes mellitus. J Clin Endocrinol Metab. 1996:81:4059～4067
-
4Beiley CJ. Biguanides and NIDDM. Diabetes Care, 1992,15:55～72
-
5彭定琼,高妍,陈宇,郭晓蕙,马红.二甲双胍对OLETF大鼠靶组织内胰岛素受体底物-1蛋白表达水平的影响[J].中国糖尿病杂志,2000,8(6):348-351. 被引量：5
二级参考文献11
-
1T. Sato,Y. Asahi,K. Toide,N. Nakayama.Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a new model of NIDDM[J].Diabetologia.1995(9)
-
2Wildasin EM,Skaar DJ,Kirchain WR,et al.Metformin, a promisingoral antihyperglycemic for the treatment of noninsulin-dependentdiabetes mellitus[].Pbarmacotherapy.1997
-
3Kawano K,Hirashima T,Mori S,et al.Spontaneous long-termhyperglycemic rat with diabetic complication: Otsuka Long-EvansTokushima Fatty(OLETF) strain[].Diabetes.1992
-
4Mario JA Saad,Frenco F,Jeffrey A,et al.Modulation of insulinreceptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexametbasone-treated rats[].The Journal of Clinical Investigation.1993
-
5Hotamisligil G,Budavari A,Murray D,et al.Reduced tyrosine kinaseactivity of the insulin receptor in obesity-diabetes.Central role of tumor necrosis factors[].The Journal of Clinical Investigation.1994
-
6Ahmad F,Goldstein BJ.Alterations in specific protein-tyrosinephosphatases accompany inslin resistance of streptozotocin diabetes[].American Journal of Physiology.1995
-
7Saad MJA,Folli F and Kabn CR.Insulin and dexamethasone regulateinsulin receptors, insulin receptor substrate-2 andphoophatidylinositol 3-kinase in fao hepatoma cells[].The Journal of Endocrinology.1995
-
8Ishida K,Mizuno A,Sano T,et al.Effect of timely insulinadministration on pancreatic B-cell of Otsuka-Long-Evans Tokushima-Fatty (OLETF) strain rats, an animal model of noninsulin-dependent diabetes mellitus (NIDDM)[].Hormone and Metabolic Research.1995
-
9Sato T,Asahi Y,Toide K,et al.Insulin resistance in skeletal muscleof the male Otsuka Long-Evans Tokushima Fatty rat,a new model ofNIDDM[].Diabetologia.1995
-
10Stith BJ,Woronoff K,Wiernsperger N.Stimulation of theintracellular portion of the human insulin receptor by the antidiabeticdrug metformin[].Biochemcal Pharmacology.1998
共引文献4
-
1张萍,梁慧,蓝海云,陈奇盛,吴世凤,傅一明.不同方式联合药物治疗2型糖尿病继发性失效的疗效探讨[J].临床医学,2006,26(1):15-17. 被引量：1
-
2梁雪,苗明三.防治糖尿病药物筛选方法的探讨[J].中医学报,2012,27(5):600-603. 被引量：2
-
3俸东升.口服降糖药物治疗糖尿病的若干进展[J].华夏医学,2003,16(2):261-264. 被引量：7
-
4傅一明,张萍.中效胰岛素联合非磺酰脲类降糖药治疗继发性磺酰脲类药物失效的2型糖尿病[J].广西医科大学学报,2003,20(3):401-402. 被引量：1
-
1杨昱,王昆,刘超.糖尿病基础胰岛素治疗[J].中国实用内科杂志,2010,30(10):939-941. 被引量：20
-
2苏胜,张红,李锦华,邱宁.甘精胰岛素联合瑞格列奈治疗2型糖尿病的疗效观察[J].广西医学,2010,32(9):1062-1064. 被引量：18
-
3周正森.甘精胰岛素联合格列美脲治疗2型糖尿病60例临床观察[J].中国社区医师（医学专业）,2013,15(9):64-64.
-
4张艳,丁辉.甘精胰岛素联合格列美脲治疗2型糖尿病疗效观察[J].中国伤残医学,2014,22(10):167-168. 被引量：1
-
5赵红丽,吉米兰木.买买提明,张莉.2型糖尿病降糖药口服控制不理想应用格列美脲联合甘精胰岛素治疗的临床分析[J].中国医药指南,2014,12(18):183-184. 被引量：14
-
6王海荣,孟凡东.甘精胰岛素联合阿卡波糖治疗2型糖尿病临床疗效观察[J].中国保健营养（下半月）,2012,0(6):2120-2120. 被引量：3
-
7王海荣,唐义志.甘精胰岛素联合格列美脲治疗2型糖尿病的临床观察[J].中国医药指南,2012,10(17):222-223. 被引量：9
-
8姜玉东.甘精胰岛素联合瑞格列奈治疗2型糖尿病效果的临床观察[J].糖尿病新世界,2014,34(10):9-9. 被引量：1
-
9赵艳艳,冯玉欣,孙香,刘慧萍.重组甘精胰岛素与低精蛋白胰岛素联合格列美脲治疗2型糖尿病的疗效观察[J].临床合理用药杂志,2011,4(7):12-13. 被引量：11
-
10赵弋于,赵巧玲.地特胰岛素替代低精蛋白胰岛素治疗2型糖尿病的疗效评估[J].中国糖尿病杂志,2011,19(11):847-849. 被引量：5
