肺减容手术用国产牛心包垫片的研制

Experimental study of home-made bovine pericardium buttressing the staple line in lung volume reduction surgery

目的 研制开发肺减容手术用可替代昂贵进口产品的国产牛心包垫片 ,并初步验证其应用的可行性。方法 精选 2～ 3岁鲁西南牛或秦川牛之心包 ,经特殊处理加工后制成 3种不同厚度并呈“鞘状”的肺减容手术用牛心包垫片 (A1、A2 、A3 )。利用犬模型对其进行评判和筛选 ,选取操作性能 (包括钉合、切割及装卸 3方面 )及切缘耐压作为评判指标。结果 3种型别的产品多数功能指标满足要求 ,其中A3 组产品最适合临床使用。结论 肺减容手术用国产牛心包垫片在动物实验中显示了良好的性能 ,具有推广临床试用的价值。

Objective: To invent the cost efficient home made bovine pericardium buttressing the staple lines in lung volume reduction surgery, and evaluate its feasibility by the means of animal test. Methods: the bovine pericardium of certain type of cattle was chosen, and special management was applied on it, making a sheath like product especially for LVRS. A serial types named A 1, A 2 and A 3 were prepared for the dog model pre clinical experimental test. The smoothness of stapling and dividing, the effectiveness of sealing, and the endurance of pressure were recorded as the index of judgment. Results: Products of all these three types were satisfactory in different degree for utilization, while the type of A 3 was found to suit best. Conclusion: In this study, the home made bovine pericardium buttressing the staple line in LVRS showed satisfactory characteristic in the animal test, and it should have great potential value in the coming clinical use.