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膀胱移行上皮癌c-Fos蛋白的表达和意义 被引量:1

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摘要 目的 探讨c Fos蛋白 (c Fos)的表达与膀胱移行上皮细胞癌 (BTCC)发生、生物学行为和预后的关系。方法 应用免疫组化SP法检测 11例正常膀胱组织、14例癌旁组织、43例BTCC组织中c Fos的表达。结果 c Fos主要表达于多种细胞的细胞核 ,并散在表达于细胞浆 ;c Fos在BTCC组织中的表达阳性率为 48 8% ,明显高于正常组织及癌旁组织 ,差异有显著性 (P <0 0 5 ) ;c Fos在BTCC血管中的染色明显深于正常血管 ;c Fos的表达在BTCC的分级中差异有显著性 (P <0 0 5 )。结论 c Fos的表达可能与膀胱组织多种细胞功能相关 ;c Fos的过度表达与BTCC的发生关系密切 ,并可能与肿瘤血管形成相关 ;c
出处 《广东医学》 CAS CSCD 2003年第9期953-954,共2页 Guangdong Medical Journal
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