足叶乙甙联合米托蒽醌和阿糖胞苷治疗难治性复发性急性白血病

Observation of Efficacy of MVA Chemotherapy Treating Relapsing and Refractary Leukemia

目的 探索治疗难治性及复发性急性白血病的有效化疗方案。 方法 5 8例难治性复发性急性白血病患者 ,用MVA方案 8天疗法 ,即米托蒽酮 (Mx) 5～ 10mg/ (m2 .d) ,第 1～ 3天 ,静注 ,据病情可在第 8天再给 5～ 10mg/ (m2 .d) ,足叶乙甙 (VP - 16 ) 10 0mg/ (m2 .d) ,第 4～ 8天用 ,静点 (<2h)。阿糖胞苷 (Ara -c) 2 0 0mg/ (m2 .d) ,第 1～ 8天用 ,静点。 结果 CR 2 8例 ,PR 17例 ,总有效率 77 6 %。未出现严重骨髓抑制 ,大部分病人有恶心 ,呕吐等胃肠道反应。

Objective To explore effective chemotherapy regimens for relapsing and refractary leukemia. Methods 58 patients with relapsing or refractory acute leukema were treated with MVA regimen for 8 days:MX 5～10mg/(m 2.d 1～3 ),iv if needed adding 5～10mg/(m 2.d8);VP16 100mg/(m 2.d),d4～8 iv(<2h);Ara-C 200mg/(m 2.d) d1～8 ivgtt.Results There were 28 cases of complete response and 17 cases of partial response.The total effective rate was 77.6%.There was no severe myelosuppression,and most patients had gastrointestinal tract reaction such as nausea,vomitting.Conclusion The MVA is effective to treat relapsing or refractory acute leukemia.