小儿呼吸道病毒感染时C反应蛋白的变化及意义

Change of CRP and Value in Respiratory Virus Infection of Children

目的 探讨血清C反应蛋白浓度在小儿呼吸道病毒感染时的变化及其意义。 方法 采用琼脂板免疫扩散法测定CRP和酶联免疫测定法测定血清中呼吸道合胞病毒抗体、腺病毒抗体和柯萨奇病毒抗体。结果 两种以上病毒的抗体阳性时 ,血清中C反应蛋白水平升高者占 5 6 % (18/32 ) ;而单个病毒感染时 ,C反应蛋白水平均低于 10mg/L。 结论 混合性呼吸道病毒感染时 ,患儿同时伴有细菌感染的可能性较大 ,可考虑用抗生素治疗。

Objective To explore the change and value of C reactive protein (CRP) concentration in respiratory virus infection.Methods CRP was detected by agar plate immunodiffusion.Serum respiratory syncytial virus antibody,adenovirus antibody and coxsackie virus antibody were detected by ELISA.Results Serum CRP level was elevated in 56% patients (18/32) with more than two virus infection.CRP was lower than 10mg/L as single virus infection.Conclusion The patients have more possibility of bacterial infection,when they have mixed virus infection and antibiotic therapy should be considered.