干扰素α-2α对慢性丙型肝炎肝纤维化的疗效观察

Clinical Observation of Efficacy of Interferon α-2α in the Treatment of Liver Fibrosis in Chronic Hepatitis C

目的 观察干扰素α 2α对慢性丙型肝炎肝纤维化的疗效。 方法 4 2例病人随机分为两组 ,治疗组 2 2例 ,应用干扰素α 2α 5 0 0万U肌注 ,每周 3次 ,疗程 6个月 ;对照组 2 0例 ,给予复方丹参颗粒、维生素E口服 ,疗程 6个月。随访 6个月 ;定期检测ALT、HCV RNA、肝纤维化指标。 结果 治疗组的ALT复常率、HCV -RNA阴转率、肝纤维化指标在治疗结束时及随访后与对照组相比有显著性差异。 结论 干扰素α

Objective To observe clinical efficacy of interferon α 2α in the treatment of liver fibrosis in chronic hepatitis C. Methods 42 cases of chronic hepatitis C are divided into two groups at random,The treatment group with 22 patients were treated by interferon α 2α 5000000U (im) three times a week,6 months as a course;The control group with 20 patients were treated by Fu Fang Dan Shen particles and vitamin E,6 months as a course.They are both visited for 6 months.Their ALT.HCV-RNA and the indexes of fibrosis are detected periodically.Results After the treatment and the visit,there was a significant difference in the ALT normalizing rate、HCV?RNA turning-negative rate and Liver fibrosis indexes between the two.Conclusion Interferon α 2α is an effective drug in treatment of the liver fibrosis in chronic hepatitis C.