摘要
背景与目的:声门上喉鳞癌的预后较差,大量研究显示其预后与多种因素有关,但诱导型一氧化氮合酶(induciblenitricoxidesynthase,iNOS)和碱性成纤维细胞生长因子(basicfibroblastgrowthfactor,bFGF)表达与其预后的研究未见报道。本研究旨在探讨iNOS和bFGF表达在判断声门上喉鳞癌预后中的价值。方法:用LSAB法结合病理图像分析系统对64例声门上喉鳞癌组织中iNOS和bFGF蛋白的表达进行检测,研究二者与颈淋巴结转移、肿瘤复发和预后的关系。结果:(1)颈淋巴结阳性者iNOS和bFGF蛋白表达的阳性目标值分别为33.2±8.8和36.1±7.8,明显高于颈淋巴结阴性组的27.3±7.4和24.5±7.5;术后复发者iNOS和bFGF蛋白阳性目标值分别为36.9±1.7和34.6±2.0,高于无复发者的29.1±1.3和27.2±1.4,差异均有统计学意义(P<0.05)。(2)颈淋巴结阳性者的5年生存率低于阴性者(31.0%vs57.1%)。iNOS蛋白阳性表达者的5年生存率低于阴性表达者(40.0%vs77.8%),bFGF蛋白阳性表达者与阴性表达者间5年生存率的差异无统计学意义(P>0.05)。(3)Cox模型多因素回归分析显示,颈淋巴结转移、iNOS蛋白表达和术后放疗对生存的影响有统计学意义,T分期和bFGF蛋白表达不是独立的预后因素。结论:iNOS蛋白表达是独立的预后因素,但iNOS和bFGF表达对声门上喉鳞癌?
BACKGROUND &OBJECTIVE:The prog nosis of suprag lottic squamous cell carcinoma (SGSCC)was poor.To authorsknowledg e,the relationship between inducible nit ric oxide synthase(iNOS )and basic fibroblast g rowth factor (bFGF )and the prog nosis of SGSCC has not bee n addressed to date.This study was desig ned to eval uate the prog nostic sig nificance of these two parameters in SGSCC.METHODS :The expression of iNOS and bFGF protein in 64patients with SGSCC usi ng LSAB method and patholog ic imag in e analysis system and their association with neck lymph node metastases ,recurrence,and prog nosis.RESULTS :(1)The expression of iNOS and bFGF was sig nificantly hig her in cervica l lymph node positive g roup(33.2±8.8and36.1±7.8)than in neg ative g roup(27.3±7.4and 24.5±7.5)with statistical sig nificance.The expression of iNO S and bFGF was hig her in recurrence g r oup(36.9±1.7and 34.6±2.0)than in no-recurrence g roup(29.1±1.3and27.2±1.4)with statistical sig nificance.(2)Patients with positive neck lymph node had poorer 5-year survival than those with neg ative neck lymph node (31.0%vs.57.1%).Patients with positive iNOS expres sion had poorer 5-year survival than those with the neg ativ e iNOS expression(40.0%vs.77.8%).However,there was no statistical si g nificance between positive bFGF expression g roup and neg ative bFGF expression g roup.(3)Cox model multivariate reg ression analysis showed that lym ph node status,the expression of iNO S and postoperative radiotherapy were in dependent prog nosis factors ,where as the T stag ing and the expression of bFGF we re not.CONCLUSION:The expression of iNOS was one of the independent prog nostic factors ,but it is necessary to study further for iNOS and bFGF to predict t he prog nosis of patients with SGSCC u sing immunohistochemical technique.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2003年第9期978-981,共4页
Chinese Journal of Cancer