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FGF_2对体外培养牙胚冠部形态的调控作用 被引量：3

In vitro effects of FGF_2 on odontogenesis of mouse embryonic molar
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摘要 目的 :观察FGF2 对体外培养的小鼠第一磨牙牙胚冠部形态分化发育的影响。方法 :取 18d胎龄的鼠胎下颌第一磨牙牙胚 ,置于含外源性FGF2 的半固态培养基表面 ,组织学观察FGF2 对体外培养的牙胚发育的影响。结果 :经 10 μg/mlFGF2 作用的磨牙胚培养 9d后形成高耸的牙乳头尖 ,牙胚体积增大 ,牙尖及邻近部位牙乳头细胞分化为柱状或高柱状的成牙本质细胞 ,排列整齐 ,并有基质开始沉积 ,细胞分化程度、数量均高于对照组。结论 :FGF2 具有诱导牙胚组织细胞分化的功能。 Objective:To study the effect of FGF 2 on odontogenesis of mouse embryonic molar. Method:tooth germ from day-18 mouse embryonic molars were separated and cultured for up to 9 day in vitro. Result:The results indicated that Well-defined and more rapid differetiation of odontoblast and more predentin matrix were observed in FGF 2 group than those in culture group after 9 days in culture.Conclusion:The results suggested that FGF 2 might involve in regulating tooth germ development during its morphogenesis and dentinogenesis. [
作者 陆怀秀 张蓉 肖明振 牛忠英 王捍国 韩亮 林松杉 周君
机构地区 海军总医院口腔科 第四军医大学口腔医学院牙体科 解放军 赤峰市平庄矿务局总院口腔科
出处 《临床口腔医学杂志》 2003年第9期533-534,共2页 Journal of Clinical Stomatology
关键词 FGF2 体外培养 牙胚冠部形态 调控作用 牙胚发育 同源盒基因 FGF 2 hox gene tooth germ development
分类号 R780.2 [医药卫生—口腔医学]
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参考文献4

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同被引文献43

  • 1闫征斌,田卫东,刘磊,侯景秋,陈希哲,李志勇.小鼠牙胚的鸡胚培养模型的建立[J].华西口腔医学杂志,2004,22(3):232-234. 被引量：5
  • 2李纾,潘克清,葛少华,谢瑞阅,段学静,杨丕山.牙本质基质蛋白1、骨桥蛋白及骨涎蛋白在小鼠牙骨质形成中的组织学定位[J].上海口腔医学,2005,14(1):28-32. 被引量：3
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临床口腔医学杂志
2003年 第9期

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