原发性高血压红细胞CR_1分子粘附活性和胸腺素的免疫调整作用

A clinical study on the activity of complex recepter type on (CR_1) on erythrocyte in patients with essential hypertension and regulatory action of thymosin

目的 :探讨原发性高血压 (EH)红细胞免疫 (redcellimmuneadherence ,RCIA)病理机制和胸腺素的非特异性免疫调整作用。方法 :以酵母菌红细胞花环试验及PEG沉淀法测定 99例EH者红细胞C3b受体 (RCR)活性、红细胞粘附免疫复合物(RICR)指标及循环免疫复合物 (CIC)含量。并使用小牛胸腺素随机对其中 4 8例EH进行免疫治疗 ,同时与 5 1例常规治疗EH者及 30例正常人在治疗前后对照上述指标。结果 :各期EH均出现RCR、RICR和CIC指标的显著异常 (P <0 0 1或P <0 0 5 )。免疫治疗组 12周后各上述指标较对照组有显著改善 (P <0 0 1或P <0 0 5 ) ,且对Ⅰ期EH的调整效果优于Ⅲ期组。结论 :RCIA功能障碍参与了EH动脉壁炎症损害的免疫病理过程。使用胸腺素对调整上述免疫异常具有一定作用。

Objective:To investigate the pathogenesis related with the function of the red cell immune adherence(RCIA) in the patients with essential hypertension(EH) and the possibility of the nonspecific immunol regulation.Methods:Parameters of 99 EH patients were detected by the mixed rosett of erythrocyte and yeast,PEG pracipatation respectively and were compared between 48 of whom pre and post treatment with thymosin and the control group.Results:The activity of RBC CR 1 in EH group was lower than that of normal group (P<0 01),but the ratio of RBC IC rostte (RICR)and the content of CIC was increased significantly (P<0 01,P<0 05).The changes were observed in the group of thymosin treatment that the most of parameters of RCIA function were closed to the normal (P<0 05) 12 weeks later.Conclusion:RCIA function disturbance was involved in immunopathy of EH and thymosin would improve the abilities of RBC to clear CIC and reduce the artery imflammatory injury in EH patients. [