摘要
目的:用HPLC法测定癫痫患者血液与唾液中苯巴比妥的浓度,对两者之间的相关性进行研究,考查是否可以在临床药物监测中用唾液代替血液作为检测样本。方法:测定癫痫患者血液与唾液中苯巴比妥的浓度,采用数理统计的方法对两者之间的相关性进行研究。结果:血液与唾液中苯巴比妥浓度之间具有良好的相关性.结论:在临床药物监测中,可以用唾液代替血液作为检测样本。
Objective: To determine the concentration of phenobarbital in patients plasma and saliva with HPLC, study their relativity, inspect the possibility of using saliva instead of plasma in clinical monitoring of phenobarbital. Methods: The concentration of phenobarbital in epilepsy patients'plasma and saliva was determined, and their relativity was studied by statistic methods. Results: The relativity of the concentration of phenobarbital in patients'plasma and saliva was quite good. Conclusion: It is possible to use saliva instead of plasma in clinical monitoring of Phenobarbital.
关键词
血液
唾液
苯巴比妥
浓度
相关性
研究
phenobarbital
clinical monitoring of drugs
plasma
saliva
relativit
