氯化-3-氰-2-羟丙基三甲胺的合成

Study on the Synthesis of 3-Cyano-2-hydroxypropyl Trimethylamine Chloride

研究了氯化 3-氯 - 2 -羟丙基三甲胺 ( CHPTMA)氰化反应生成氯化 3-氰 - 2 -羟丙基三甲胺的工艺 ,得到了最佳工艺条件 :反应温度 40～ 45°C,反应时间 1 .5 h,物料配比 n( CHPTMA) ∶ n( Na CN) 为 1∶1 .0 5。在此条件下 ,产率为 78.8%。

The synthesis of 3-cyano-2-hydroxypropyl trimethylamine chloride by cyanation of 3-chloro-2-hydroxy-propyl trimethylamine chloride was studied. The optimum reaction conditions were: reaction temperature, 40～45°C; reaction time, 1.5 h; n CHPTMA∶n NaCN ratis, 1∶1.05. Under these conditions, the yield was 78.8%.