盐酸诺氟沙星防治家蚕细菌病的药理学研究

Studies on the Pharmacodynamics of Norfloxacin Hydrochloride Controlling Bacterial Disease of Silkworm

盐酸诺氟沙星是一种氟喹诺酮类抗生素 ,已作为新一代蚕用抗生素应用。体外抑菌试验表明 ,在相同浓度下 ,盐酸诺氟沙星对家蚕 3种病原细菌的抑菌效果好于氯霉素和红霉素 ;生物试验表明 ,该药对家蚕常见细菌病有较好的防治效果 ,并且对家蚕的生长发育及茧质均无不良影响 ;研究其在家蚕体内的药代动力学发现 ,盐酸诺氟沙星在家蚕食下 0 2 5h后进入血液 ,0 5h后达到最大值 ,2 4h后在血液中已检测不到。

Norfloxacin Hydrochloride is a kind of Fluoroquinolones antibiotics. Inhibition in vitro experiment showed that: it had better inhibiting effect on three bacteria than other antibiotics at the same concentration, the diameter of inhibition of Norfloxacin Hydrocloride was bigger than that of chloromycetin. Biological assay also proved the same result, which was effective on controlling silkworm bacterial disease, and had no influence on silkworm growth and development and cocoon quality. The pharmacokinetic experiment showed that Norfloxacin Hydrochloride appeared in blood after it had been taken a quarter of hour, the peak time was half an hour, and it was disappeared in blood after 24 hours.