胃结直肠癌患者手术前后贫血状况的多中心临床调查研究

目的:调查比较手术治疗前后胃癌及结直肠癌病患的贫血状况。方法:以我市5家医院在2010年2月~2011年2月间收治的131例胃癌、结直肠癌病患为对象,其中,66例为胃癌,65例为结直肠癌,在术前及术后7d对患者静脉血行血红蛋白、铁蛋白、血清铁实施检测,比较手术前后贫血情况。结果:66例胃癌患者术前、术后肿瘤性贫血发生率分别为36.36%(24/66)、63.64%(42/66),缺铁性贫血发生率分别为50.00%(12/24)、73.81%(31/42),术后发生率均显著高于术前,P<0.05。65例结直肠癌患者术前、术后肿瘤性贫血发生率分别为38.46%(25/65)、58.46%(38/65),缺铁性贫血发生率分别为65例结直肠癌患者中肿瘤性贫血术前发生率为38.46%(25/65)、58.46%(38/65),术后均明显地高于术前,P<0.05。贫血患者平均年龄为(60.5±13.4)岁,无贫血患者为(57.5±11.6)岁,前者高于后者,P<0.05。结论:以外科手术为胃癌及结直肠癌患者施治,会提升患者的肿瘤性贫血及缺铁性贫血发生率,这一症状在年龄较高患者中表现尤为明显。在治疗过程中,需要加以积极地药物或食物干预。

Objective: To investigate comparison before and after surgery for gastric cancer and colorectal cancer patients with anemia condition.Methods: Selection 5 hospitals in February 2010 to February 2011 between the treated 131 cases of gastric cancer, colorectal cancer patients, among them, 66 cases of gastric cancer, 65 cases of colorectal cancer, patients with preoperative and postoperative 7 d for venous blood hemoglobin, serum ferritin and iron implement detection, anemia compared before and after surgery.Results: 66 cases of gastric cancer patients with preoperative and postoperative tumor incidence of anemia were 36.36%(24/66)and 63.64%(42/66), the incidence of iron deficiency anemia were 50.00%(12/24)and 73.81%(31/42), the incidence of postoperative were significantly higher than that of preoperative, P < 0.05).65 cases of colorectal cancer patients with preoperative and postoperative tumor incidence of anemia were 38.46%(25/65)and 58.46%(38/65), incidence of iron deficiency anemia, respectively in 65 patients with colorectal cancer tumor anemia incidence of preoperative 38.46%(25/65)and 58.46%(38/65), were significantly higher than that of preoperative, postoperative P < 0.05).Anemia in patients with an average age was(60.5 ± 13.4),(57.5±11.6) for patients with anemia, the former is higher than the latter, P < 0.05).Conclusion: Surgery for gastric cancer and colorectal cancer patients, providing will enhance the patient’s tumor incidence of anemia and iron deficiency anemia, the symptoms in patients with higher age especially.In the process of treatment, need to be actively food or drug intervention.