胎儿纤维连接蛋白与早产预测

目的:研究胎儿纤维连接蛋白(fetal fibronectin,fFN)对先兆早产孕妇发生早产的预测价值。方法:选择我院及省妇幼保健院产科门诊对有先兆早产症状并住院行保胎治疗的孕晚期孕妇56例进行阴道后穹窿分泌物中fFN的测定,追踪性分析其妊娠结局,评价胎儿纤维连接蛋白检测与早产预测的关系。结果:宫颈分泌物阳性者临产时孕周明显短于阴性组(P<0.01),而且80.6%发生早产,敏感性为88.5%,特异性为48.0%。结论:孕妇宫颈分泌物f FN阳性,是预测先兆早产及保胎治疗时间长短的敏感、可靠指标。阴性预测短期内不发生早产的价值较大。

Objective: to study the fetal protein fiber connection(fetal fibronectin, fFN) predictive value of aura preterm pregnant women preterm delivery. Methods: our hospital and provincial maternal and child health care with aura symptoms and premature maternity clinic hospital line spuc treatment of 56 cases were pregnant women late in pregnancy vagina secretion fFN determination in the vault, traceability analyze the pregnancy outcomes, and to evaluate fetal fiber connection protein detection and predict the relationship between premature. Results: the cervical secretion was giving birth gestational age is much shorter than the negative group(P < 0.01), and 80.6% of preterm delivery, sensitivity of 88.5%, specificity of 48.0%. Conclusion: pregnant women cervical secretion fFN is positive, is predicting aura prematurity, spuc sensitive, reliable indicator for the length of treatment time. When negative in the short term will not occur premature value is bigger.