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探讨帕立骨化醇抑制血管紧张素活性减轻足细胞损伤的有效性

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摘要 目的:本次主要对帕立骨化醇抑制血管紧张素活性减轻足细胞损伤的有效性进行探讨。方法:将雄性SD大鼠的右肾切除,并将其左肾动脉前肢结扎以此来诱导尿毒症的模型。选取20只尿毒症大鼠并将其随机分为两组,分别为对照组(正常SD大鼠),观察组(尿毒症大鼠)实验组(尿毒症+帕立骨化醇治疗),对三组大鼠的生化指标以及尿液指标进行分析对比。结果:观察组生化与尿液指标均显著高于对照组,P<0.05,两组数据的对比差异性有统计学的意义;结论:帕立骨化醇能够与抑制血管紧张的素活性,并减轻足细胞的脱落与损伤。
机构地区 定州市人民医院
出处 《中国妇幼健康研究》 2016年第S2期221-222,共2页 Chinese Journal of Woman and Child Health Research
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