虫草补肾胶囊、五子衍宗丸治疗少弱精子症的临床疗效比较

目的:比较虫草补肾胶囊、五子衍宗丸治疗少弱精子症患者的方法、疗效和安全性。方法:选取少弱精子症患者100例,随机分为观察组与治疗组,每组各50例。对照组予以五子衍宗丸治疗,观察组予以虫草补肾胶囊治疗,两组均治疗3个疗程。于治疗前、治疗3个疗程后,进行精液常规检查、生殖激素水平检测,记录近期患者配偶妊娠率及治疗期间的不良反应,进行疗效评定。结果:治疗3个月后,两组精子量、精子密度、活动率及活力均有所提升,血清T水平均升高,LH、FSH和PRL水平均降低(P<0.05或P<0.01),且观察组精子量、精子密度、活动率、活力以及血清T水平均高于对照组,LH、FSH和PRL水平低于对照组(P<0.05)。观察组、对照组总有效率分别为87.50%、69.57%,配偶妊娠率为20.83%、8.51%(P<0.05)。除个别轻微皮肤、胃肠道反应外,均未见其他明显的不良反应。结论:虫草补肾胶囊治疗少弱精子症具有较好的临床疗效,有效改善了精液质量,调节了生殖激素水平,配偶妊娠率高,且具有较高的安全性,对少弱精子症患者的临床治疗具有一定的借鉴意义。

Objective:To compare Cordyceps Bushen capsule, Wuziyanzong pill treatment method, in patients with less weak sperm efficacy and safety. Methods:100 cases of patients with the disease were randomly divided into the observation group and the treatment group, 50 cases in each group. The control group was given Wuziyanzong pill treatment, the observation group received Cordyceps Bushen capsule treatment, two groups were treated for 3 courses. Before treatment, after 3 courses of treatment, semen routine examination, reproductive hormone level test, record the recent pregnancy rate and the adverse reaction of the treatment period, the evaluation of curative effect. Results:3 months after treatment, two groups of sperm volume, sperm density and activity rate and enhance the activity of serum T, LH and FSH was increased, and the level of PRL decreased(P < 0.05 or P < 0.01), and the sperm quantity, sperm density, motility and serum level of T was higher than that of control group observation, LH, FSH and PRL were lower than those of control group(P < 0.05). The total effective rate of the observation group and the control group were 87.50% and 69.57% respectively, and the pregnancy rate was 20.83% and 8.51%(P < 0.05). Except for some minor skin and gastrointestinal reactions, there were no obvious adverse reactions. Conclusion:Cordyceps Bushen capsule in treating oligoasthenozoospermia has good clinical curative effect, can effectively improve semen quality, regulate the reproductive hormone level, pregnancy rate is high, and has higher security, less on the clinical treatment of patients with weak sperm has a certain significance.