系统性红斑狼疮合并妊娠患者联合免疫治疗效果评价

目的:探讨系统性红斑狼疮(SLE)合并妊娠患者联合免疫治疗效果。方法:分析2010年1月-2015年12月我院收住的68例SLE合并妊娠患者与胎儿的临床资料进行分析,根据妊娠前激素联合免疫抑制剂治疗组36例(组1)和单一激素治疗组32例(组2),其中组1妊娠前停用免疫抑制剂3-6月,比较各组的妊娠前1个月、妊娠中、产时及产后1月泼尼松用量、疾病活动性情况(SLEDAI评分)、妊娠结局进行分析。结果:组1及组2患者不同时期泼尼松用量差异、疾病活动性、妊娠结局有统计学意义。结论:SLE合并妊娠前联合使用免疫抑制剂有利于SLE病情稳定,改善妊娠结局,提高活产率。

Objective:Systemic lupus erythematosus(SLE) immunotherapy pregnancy outcomes. Methods:Analysis January 2010-December 2015 admitted to our hospital clinical data of 68 cases of SLE patients with pregnancy and fetal analyzed, combined with immunosuppressive treatment group of 36 patients(group 1) in accordance with a single before pregnancy hormones and hormone therapy group 32 patients(group 2), of which the first group 1 pregnancy weaned from immunosuppression from March to June, before pregnancy compare each group a month, pregnancy, intrapartum and postnatal January prednisone, disease activity case(SLEDAI score), pregnancy outcomes were analyzed. Results:Group 1 and group 2 patients with different stages of prednisone dosage differences, disease activity, pregnancy outcome was statistically significant. Conclusions:SLE joint use of immunosuppressive agents before pregnancy in favor of SLE in stable condition, to improve pregnancy outcomes, improve the live birth rate.