小剂量甲状腺素联合厄贝沙坦氢氯噻嗪治疗老年女性重症慢性心力衰竭的临床疗效观察

目的:探究老年女性重症慢性心力衰竭患者治疗中加用小剂量甲状腺素对疗效及不良反应等方面的影响。方法:选取我院2015年1月-2016年6月入院的老年女性重症慢性心力衰竭患者80例,随机分组法分为观察组和对照组,每一组40人。对照组治疗方法为厄贝沙坦氢氯噻嗪治疗,观察组治疗方法为小剂量甲状腺素联合厄贝沙坦氢氯噻嗪治疗。针对临床治疗有效率、不良反应发生及心功能改善情况,对两组患者进行对比分析。结果:在临床治疗效果方面,观察组治疗总有效率(95%)比对照组总有效率(75%)高(P<0.05);针对不良反应发生情况,观察组发生率(7.5%)与对照组发生率(5%)相比无明显差异(P>0.05);观察组治疗后左心室射血分数、心输出量及每搏输出量均优于对照组(P<0.05)。结论:老年女性重症慢性心力衰竭患者通过小剂量甲状腺素与厄贝沙坦氢氯噻嗪联合治疗后取得的临床成效显著,在提高治疗效果的同时,使患者心功能状况明显改善,且不良反应发生率较低,应大力推广应用。

Objective: To explore the effect of low dose thyroxine in treatment of elderly patients with severe chronic heart failure on the efficacy and adverse reactions. Methods: Eighty elderly women with severe CHF were enrolled in our hospital from January 2015 to June 2016. The patients were divided into observation group and control group randomly. The control group was treated with irbesartan hydrochlorothiazide, the treatment group was treated with low-dose thyroxine combined with irbesartan hydrochlorothiazide. The effective rate of treatment, adverse reaction and improvement of cardiac function were analyzed, and the two groups of patients were compared and analyzed. Results: In the clinical treatment, the total effective rate(95%) of the observation group was higher than that of the control group(75%)(P0.05).According to the incidence of adverse reaction, the incidence of observation group(7.5%(P> 0.05). The left ventricular ejection fraction, cardiac output and stroke volume after treatment in the observation group were superior to those in the control group(P <0.05), but no significant difference was found in the control group(5%). Conclusion: The clinical results of the elderly women with severe chronic heart failure by low dose of thyroxine combined with irbesartan hydrochlorothiazide can improve the therapeutic effect and improve the cardiac function, and the adverse reaction rate Low, should vigorously promote the application.