PCOS患者维生素D缺乏与胰岛素水平的相关性分析

目的:探讨女性多囊卵巢综合症(Polycystic Ovary Syndrome,PCOS)患者维生素D缺乏与胰岛素水平的相关性。方法:回顾性分析2014年3月至2017年3月的在我院住院并诊断为PCOS的患者45人,选取45位健康人作为对照组。分别检测维生素D水平和心血管危险因素,如胰岛素、空腹血糖、血脂,以及性腺激素等。比较病例组及对照组维生素D水平及心血管危险因素的差异,并进行相关性分析。结果:通过T检验和Pearson相关分析发现病例组较对照组维生素D的水平更低,胰岛素水平偏高(P <0.05)。相关性分析表明PCOS患者中维生素D缺乏与胰岛素及胰岛素抵抗指数HOMA-IR(Homeostatic Model of Assessment-Insulin Resistance Index)相关(r=-0.172,P <0.05)。结论:PCOS患者更容易出现维生素D缺乏,这可能与PCOS患者内分泌代谢紊乱所致胰岛素抵抗相关。

Objective:To investigate the relationship between vitamin D level and insulin in PCOS patients. Method: To analysis 45 PCOS patient as case group and 45 healthy people as control group during 2014.MAR to 2017.MAR in our hospital. All individuals were tested vitamin D level and other index like insulin, fasting blood glucose, lipid and hormone level. Result: We found a lower vitamin level and higher level of insulin in the case group. By using Pearson regression, we found that vitamin D level is related to HOMA-IR in PCOS group(r=-0.172,P <0.05). Conclusion:Patient with PCOS is more likely to have vitamin D deficiency, which may caused by insulin resistance.