帕瑞昔布复合不同剂量右美托咪定对开胸手术苏醒期的影响

目的:研究帕瑞昔布复合不同剂量右美托咪定对开胸手术患者术后苏醒期的影响。方法:选取胸外科行食管癌根治术患者60例,随机分为A组、B组、C组共3组。关膈肌时3组患者均给予帕瑞昔布40mg;术毕前10min给予A组、B组、C组右美托咪定剂量分别为0.2μg/kg、0.4μg/kg、0.6μg/kg。分别比较3组患者呼吸恢复时间、拔管时间、不良反应情况;拔管时及拔管后5、10min循环状态。结果:3组患者呼吸恢复和拔管时间比较无统计学差异(P>0.05);C组患者拔管即刻及拔管后5、10min时心率明显低于A组、B组(P<0.05),A、B两组间比较差异无统计学意义(P>0.05);3组患者平均动脉压比较差异无统计学意义(P>0.05);A组患者术后躁动发生率较高为20%,而B组和C组患者无术后躁动发生。结论:帕瑞昔布联合0.4μg/kg右美托咪定即可使患者苏醒较好,有利于开胸手术患者临床推广。

Objective:To study the effects of parecoxib combined with different doses of dexmedetomidine on the recovery period of patients undergoing thoracic surgery. Method:A total of 60 patients undergoing radical resection of esophageal carcinoma were randomly divided into group A, group B and group C. Gived parecoxib 40 mg when the three groups of patients were closed the diaphragm. The dose of dexmedetomidine in group A, group B and group C was 0.2μg/kg, 0.4μg/kg and 0.6μg/kg, respectively, 10 minutes before operation. The time of respiratory recovery, the time of extubation and the adverse reaction were compared between the three groups, and compared the circulatory status was 5,10 min after extubation. Result:The heart rate of group C was significantly lower than that of group A and group B at 5 and 10 min after extubation(P <0.05). There was no significant difference between group B and group C(P> 0.05). There was no significant difference in the mean arterial pressure between the two groups(P>0.05). There was no significant difference in mean arterial pressure between the three groups(P> 0.05). Patients in group A after the agitation rate was as high as 20%, while the B group and C group of patients without postoperative agitation. Conclusion:Parecoxib combined with 0.4μg/kg dexmedetomidine can make patients wake up better, is conducive to thoracotomy surgery in patients with clinical promotion.