慢性阻塞性肺疾病急性加重期患者治疗中降钙素原变化的临床分析

目的:探讨血清降钙素原(PCT)对慢性阻塞性肺疾病急性加重期(AECOPD)患者抗菌药物应用的临床指导价值。方法:回顾总结和比较2013年1月～2013年12月我院呼吸内科住院治疗的116例AECOPD患者,分为PCT指导治疗组(60例)和常规治疗组(56例),分别观察抗菌药物的使用率、使用天数、住院天数、临床有效率,并比较这些指标的变化情况。结果:PCT指导治疗组的抗菌药物使用率显著少于常规治疗组(88.33%vs 100%, p<0.05),抗菌药物使用天数(8.40±0.74 d vs. 11.50±1.03, p<0.05)、住院天数(9.01±1.71 d vs. 113.92±1.76 p<0.05)明显短于常规治疗组,临床有效率比较无显著性差异(88.33%vs. 87.50%; p>0.05)。结论:PCT作为细菌感染的敏感指标之一,可作为指导临床及时、正确使用或减停抗菌药物的一个指标。

Objective:Study of serum procalcitonin(PCT) on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) antibiotics in clinical value. Methods:Review and compare the January 2013 ～2013 year in December 116 cases of AECOPD patients hospitalized in our hospital respiratory department of internal medicine, Were randomly divided into PCT treatment group(60 cases) and routine treatment group(56 cases), the rate of antibiotic use, use number of days, days of hospitalization, clinical efficacy were observed, and compared the changes of these indexes. Results:PCT guided group antibacterial drug usage was significantly less than that in conventional treatment group(88.33% vs 100%, P < 0.05), antimicrobial drug use days(8.40 + 0.74 D vs. 11.50 + 1.03, P < 0.05), length of hospital stay(901 + 1.71 D vs. 113.92 + 1.76, P < 0.05) was significantly shorter in the conventional therapy group, clinical efficiency showed no significant difference(88.33% vs. 87.50%, P > 0.05). Conclusion:PCT is a sensitive indicator of bacterial infection, an index can be used to guide clinical timely and correct use or withdrawal of antibacterial drugs.