间断禁食对非酒精性脂肪肝脂质过氧化作用的影响

目的研究间断禁食对非酒精性脂肪肝脂质过氧化是否有影响。方法选择65名非酒精性脂肪肝患者,分为实验组和对照组。实验组要求间断禁食,对照组进食时间不受限制。测定实验前后血清胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、血清丙二醛、超氧化物歧化酶、谷胱甘肽过氧化物酶水平。结果间断禁食后血清胆固醇、甘油三酯、低密度脂蛋白、血清丙二醛明显降低,高密度脂蛋白、超氧化物歧化酶、谷胱甘肽过氧化物酶水平明显升高,与对照组比较差异有统计学意义(p<0.05)。结论间断禁食具有调血脂和抗脂质过氧化作用,明显改善非酒精性脂肪肝的代谢紊乱。

Objective:To investigate whether intermittent fasting can affect lipid peroxidation in nonalcoholic fatty liver disease.Methods:Methods 65 patients with nonalcoholic fatty liver disease were divided into two groups: experimental group and control group. The experimental group required intermittent fasting, and the control group was free of food restriction. The levels of serum cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, serum malondialdehyde, superoxide dismutase and glutathione peroxidase(GSH PX) were measured before and after the experiment.Results:After intermittent fasting,Cholesterol, triglyceride, low-density lipoprotein, serum malondialdehyde decreased significantly. The levels of high-density lipoprotein, superoxide dismutase and glutathione peroxidase increased significantly, the difference was statistically significant compared with the control group(P < 0.05).Conclusion:Intermittent fasting can adjust the blood lipid and lipid peroxidation、anti lipid peroxidation and improve the metabolic disorder of nonalcoholic fatty liver disease.