GRP78、ERP57在宫颈病变过程中的表达及意义

目的:探讨GRP78、ERP57在宫颈病变过程中的表达及意义。方法:用免疫组化法对25例宫颈炎组织,32例宫颈上皮内瘤变组织,43例宫颈癌组织的石蜡标本进行GRP78、ERP57的检测。结果:随着宫颈病变的进展,GRP78的表达率呈递增趋势(P<0.05)。GRP78在宫颈癌中的表达率随着细胞分化程度的降低而增高。随着宫颈病变的进展,ERP57的表达率呈下降趋势(P<0.05)。ERP57在宫颈癌组织中的表达率随着细胞分化程度的降低、临床分期的升高、伴有淋巴转移而降低,但与年龄、组织类别无明显相关性(P>0.05)。宫颈癌中GRP78与ERP57之间表达呈一定的负相关性,P<0.05。结论:结论:GRP78、ERP57均可作为宫颈病变的相关指标。

Objective:To investigate the expression and significance of GRP78 and ERP57 in cervical lesions. Methods: the paraffin sections of 25 cases of cervicitis, 32 cases of cervical intraepithelial neoplasia and 43 cases of cervical cancer tissues were detected by immunohistochemistry, and GRP78 and ERP57 were detected by immunohistochemistry. Results: with the progression of cervical lesions, the expression rate of GRP78 showed an increasing trend(P<0.05). The expression rate of GRP78 in cervical cancer increased with the decrease of cell differentiation. With the progression of cervical lesions, the expression rate of ERP57 decreased(P<0.05). The expression rate of ERP57 in cervical cancer decreased with the decrease of cell differentiation, the increase of clinical stage and lymph node metastasis, but there was no significant correlation with age and tissue type(P>0.05). There was a negative correlation between the expression of GRP78 and ERP57 in cervical cancer, P<0.05. Conclusion: GRP78 and ERP57 can be used as indicators of cervical lesions.