邢台市126例新生儿先天性甲状腺功能减低症围产因素分析

目的:探讨邢台地区先天性甲状腺功能减退症(CH)与围产期相关因素的关系。方法:选取2015年1月-2017年5月在邢台市疾病筛查中心被诊断为先天性甲状腺功能减低症(CH)的新生儿126例,再随机选取非CH的新生儿126例作为对照组。在对CH的围产期因素进行分析的时候采用单因素的分析方法。结果:单因素结果显示:新生儿CH发生率与高龄,早产,低体重,巨大儿,过期产无统计学意义(P>0.05);新生儿CH发生率与妊娠期高血压、妊娠期糖尿病、妊娠期感染、甲亢、甲减、年龄段等关系密切(P<0.05);多因素Logistic回归分析结果显示:新生儿CH发生率与妊娠期高血压、妊娠期糖尿病、妊娠期感染、甲亢、甲减、年龄段等关系密切(P<0.05)。结论:新生儿的先天性甲状腺功能减低症与其母亲妊娠期的高血压、妊娠期合并甲状腺疾病、妊娠期糖尿病、年龄段及妊娠早期感染性疾病有关,新生儿CH的发病率与高龄以及新生儿是否早产、过期、新生儿体重不相关,新生儿女性的先天性甲状腺功能减低症的发生率高,因此在孕期期间各位孕妇要做好孕期保健工作,尽量减少会造成CH发生的因素,从而降低CH的发生概率。

Objective:To investigate the relationship between congenital hypothyroidism(CH) and perinatal factors in Xingtai. Methods:a total of 126 neonates diagnosed with congenital hypothyroidism(CH) at the Xingtai municipal disease screening center in January 2015 May were selected, and 126 neonates without CH were randomly selected as control group(-2017). Single factor analysis was used to analyze perinatal factors in CH. The results:of univariate results showed that neonatal CH incidence and age, premature birth, low birth weight, fetal macrosomia, overdue no statistical significance(P>0.05); Conclusion:neonatal congenital hypothyroidism in pregnancy and reduce hypertension, pregnancy complicated with thyroid disease, neonatal weight, congenital thyroid function of newborn females reduce the occurrence of disease rate is high, so in pregnancy during all pregnant women to good antenatal care, reduce the cause factors of CH, so as to reduce the probability of occurrence of CH.